Description

Tau protein(microtubule-associated protein tau) is a protein that plays a supporting role in the axons of neurons. It through the regulation of microtubule stability to maintain the structure and function of neurons. In AD patients, tau protein undergoes abnormal phosphorylation and aggregation, forming neurofibrillary tangles, leading to the destruction of neuronal structure and loss of function. Studies have shown that the level of tau protein in the cerebrospinal fluid of AD patients is significantly increased, and the degree of increase is positively correlated with the degree of cognitive decline. In addition to tauF, tauB, tauC, tauD, tauE and Fetal-tau are expressed in human brain. tau protein, as a marker for the diagnosis of Alzheimer’s disease, provides strong support for early intervention and treatment. Description HKIG’s innovative product: tau (non-phospho) antigen isomer set, which has the following characteristics:

1. 1. It is expressed in mammalian cells to maintain the conformation of the protein in human physiological state.
2. 2. The important phosphorylation sites (pT181, pT217, pT231, etc.) did not contain phosphorylation.
3. 3. Covering the full length of the protein, no label, no modification, high purity, close to the natural protein structure to the greatest extent.

1. Authenticity and phosphorylation

Indirect ELISA showed that the protein was authentic and had no phosphorylation at key sites (181, 217, 231).