Filters Sort results
Reset Apply
 | Induction of glial fibrillary acidic protein (GFAP), a hallmark intermediate filament (IF) in astrocytes that contributes to synapse formation and axonal metabolic homeostasis in the central nervous system, is essential for the formation of an astrocytic process (astrocytosis) during nerve repair. Chronic reactive astrocytosis is associated with several neuroinflammatory and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. GFAP is also considered as one of the markers for the diagnosis of AD. | |
 | Human epididymal protein 4 (HE4) was first discovered in human distal epididymal epithelial cells. Human epididymal protein 4 and CA125 levels have a strong correlation in the diagnosis and treatment of ovarian cancer patients, and serum HE4 levels can be used as tumor markers to evaluate the efficacy of ovarian cancer treatment [1]. HKIG currently … Human Epididymal Protein 4 (HE4)">Continue reading Human Epididymal Protein 4 (HE4) | |
| Neurofilament L, a subunit of neurofilaments (Nfs), is a cylindrical protein located in the cytoplasm of neurons. Neurofilaments play an important role in the structural stability of neurons, which are present in dendrites, axons and neuronal bodies. Only a small amount of NfL is released under normal circumstances. However, when the nervous system is damaged by inflammation, trauma or neurodegeneration, the release of NfL will increase dramatically. It can be spread through the CSF to blood, body fluids, the content of the NfL and neurologic injury is closely related to the disease. Therefore, NfL is also used as a diagnostic marker for neuronal injury diseases. | |
| Pepsinogen (PG) is a single-chain polypeptide composed of 375 amino acids that belongs to the aspartate protein family. Human pepsinogen can be divided into seven isoenzymes, of which pg1-pg5 has common immunogenicity, known as PG I; pg6 to pg7 has a slower migration rate and is called PG II. The change of serum PG level … Pepsinogen I">Continue reading Pepsinogen I | |
| Pepsinogen (PG) is a single-chain polypeptide composed of 375 amino acids that belongs to the aspartate protein family. Human pepsinogen can be divided into seven isoenzymes, of which pg1-pg5 has common immunogenicity, known as PG I; pg6 to pg7 has a slower migration rate and is called PG II. The change of serum PG level … Pepsinogen II">Continue reading Pepsinogen II | |
| Tau protein(microtubule-associated protein tau) is a protein that plays a supporting role in the axons of neurons. It through the regulation of microtubule stability to maintain the structure and function of neurons. In AD patients, tau protein undergoes abnormal phosphorylation and aggregation, forming neurofibrillary tangles, leading to the destruction of neuronal structure and loss of function. Studies have shown that the level of tau protein in the cerebrospinal fluid of AD patients is significantly increased, and the degree of increase is positively correlated with the degree of cognitive decline. Tau protein as AD diagnostic marker for early intervention and treatment provides a strong support. |