Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease. When the disease affects the nervous system and the parts of the body under nervous control, the symptoms of the disease gradually appear. The most common symptoms of Parkinson’s disease include resting tremor, myotonia and bradykinesia. In addition, postural balance disorders, olfactory disorders, sleep disorders and cognitive disorders can also occur. There is no complete cure for Parkinson’s disease, but it can be improved by treatment to prevent further aggravation of the disease. Parkinson’s disease is more common in the elderly, with an average onset age of about 60 years old, and it is rare in people under 40 years old, and it is more common in men than in women. There are currently more than 3 million Parkinson’s disease patients in China, and it is expected that the number of Parkinson’s disease patients in China will reach 5 million by 2030.
In the brain of patients with Parkinson’s disease, neurons gradually break down and die, which leads to abnormal brain activity and Parkinson’s disease symptoms. Pathological changes in the brain of patients with Parkinson’s disease include the formation of Lewy bodies, characterized by the degeneration and death of dopaminergic neurons, especially in the substantia nigra region of the brainstem. The pathogenesis of PD is not fully understood, but it is known to be associated with multiple factors such as genetics, environment and age. The typical pathological change in Parkinson’s disease is the appearance of specific substances in the brain cells clumps, known as Lewy bodies. Researchers have found many substances in Lewy bodies, but after analyzing them, they think that α-synuclein is more important.
α-synuclein is present in clumps in all Lewy bodies, and cells are unable to disassemble these clumps. Protein misfolding and aggregation are thought to be important in the pathogenesis of Parkinson’s disease, and oligomers formed at the early stage of polymerization are considered to be potent neurotoxic substances.
HKIG Parkinson’s disease antigen product
HKIG Innovative products：alpha-synuclein antigen. The antigen protein is expressed in mammalian cells, covering the full length of the protein, with high purity, and maintaining the native protein conformation to the greatest extent, which is helpful for the accurate quantitative detection of disease-related indicators.
| Name | Catalog No. | Size |
| alpha-synuclein antigen | 2059 | 50μg/100μg |
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