Product launch: tau-758 (phosphorylation) antigen

Alzheimer’s Disease (AD) is an irreversible degenerative disease of the central nervous system. It is initially manifested as short-term memory impairment, and then gradually develops into comprehensive cognitive dysfunction. It mainly occurs in the elderly. At present, there are about 10 million patients with Alzheimer’s disease in China, and this number will further increase with the deepening of aging.

Alzheimer’s disease biomarkers

The pathological features of Alzheimer’s disease usually include β-amyloid (Aβ) deposition and neurofibrillary tangles, accompanied by neurodegeneration and neuroinflammation.

Aβ40、Aβ42

The amyloid precursor APP generates Aβ protein through the amyloid hydrolysis pathway in patients with Alzheimer’s disease, with most and less of the protein produced as Aβ40. The spontaneous aggregation of Aβ proteins forms neurotoxic deposits, which mechanistically induce toxicity to the nervous system. Currently, elevated plasma levels of Aβ40 and Aβ42 are thought to be associated with Alzheimer’s disease.

Tau、tau isoforms

Tau is a microtubule-associated protein with physiological functions such as stabilizing microtubules and assisting axonal transport. In Alzheimer’s disease patients, tau protein will have abnormal modification behaviors, such as hyperphosphorylation and aggregation, and eventually form neurofibrillary tangles, leading to the abnormal and loss of neuronal function and affecting the nervous system. In addition to the full-length Tau representative sequence, tauB, tauC, tauD, tauE, tauF and Fetal-tau are associated with Alzheimer’s disease.

NfL、GFAP

Alzheimer’s disease is associated with neurodegeneration and neuroinflammation. Neuronal degeneration releases cytoskeletal proteins, including neurofilament light chains (NfL), which are currently considered as non-specific biomarkers of Alzheimer’s disease. Neuroinflammation leads to changes in the level of glial fibrillary acidic protein (GFAP) in body fluids, which is currently regarded as a non-specific biomarker of Alzheimer’s disease. This marker changes first in the preclinical stage and is considered to be useful for early asymptomatic screening of Alzheimer’s disease.

Alzheimer’s disease antigen product

HKIG Innovative product: Tau758 phosphorylated protein antigen. The antigen protein is expressed in mammalian cells, covering the full length of the protein, with high purity, and maintaining the native protein conformation to the greatest extent, which is helpful for the accurate quantitative detection of tau protein. HKIG focuses on the development of diagnostic raw materials related products. At present, there are 9 Alzheimer’s disease-related antigen protein products, which help the quantitative detection of related indicators.

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