Description

Pepsinogen (PG) is a single-chain polypeptide composed of 375 amino acids that belongs to the aspartate protein family. Human pepsinogen can be divided into seven isoenzymes, of which pg1-pg5 has common immunogenicity, known as PG I; pg6 to pg7 has a slower migration rate and is called PG II. The change of serum PG level is a clinical indicator of gastric cancer and gastric mucosal carcinoma. The lower the ratio of serum PG I to PG II, the higher the incidence of gastric cancer occurs ^[1].

HKIG offers two monoclonal antibodies for detecting PG I (1013101 and 1013201).

Anti PG I monoclonal antibody

Example of PG I standard curve (CLIA)

Capture antibody: 1013101, Detection antibody: 1013201. R²>0.99 LoB<0.2ng/mL

Reference：

【1】Journal of Gastroenterological Mass Survey, 1994, 32(3):21-27.