Description

Tau protein(microtubule-associated protein tau) is a protein that plays a supporting role in the axons of neurons. It through the regulation of microtubule stability to maintain the structure and function of neurons. In AD patients, tau protein undergoes abnormal phosphorylation and aggregation, forming neurofibrillary tangles, leading to the destruction of neuronal structure and loss of function. Studies have shown that the level of tau protein in the cerebrospinal fluid of AD patients is significantly increased, and the degree of increase is positively correlated with the degree of cognitive decline. Tau protein as AD diagnostic marker for early intervention and treatment provides a strong support.

HKIG innovative products: Tau (non-phospho) antigen, has the following features:

1. It is expressed in mammalian cells (CHO) to maintain the conformation of the protein in human physiological state.
2. The important phosphorylation sites (pT181, pT217, pT231, etc.) did not contain phosphorylation.
3. Covering the full length of the protein, no label, no modification, high purity, and maximum close to the natural protein structure.

Non-phosphorylated tau protein is particularly suitable for use as calibrators or quality controls for total tau diagnostic kits