Description
Tau protein(microtubule-associated protein tau) is a protein that plays a supporting role in the axons of neurons. It through the regulation of microtubule stability to maintain the structure and function of neurons. In AD patients, tau protein undergoes abnormal phosphorylation and aggregation, forming neurofibrillary tangles, leading to the destruction of neuronal structure and loss of function. Studies have shown that the level of tau protein in the cerebrospinal fluid of AD patients is significantly increased, and the degree of increase is positively correlated with the degree of cognitive decline. Tau protein as AD diagnostic marker for early intervention and treatment provides a strong support.
HKIG innovative products: Tau (phosphorylation) antigen, has the following features:
- It is expressed in mammalian cells (CHO) to maintain the conformation of the protein in human physiological state.
- The phosphorylation of important sites (pT181, pT217, pT231) remained intact, which helped the phosphorylation detection of diagnostic indicators
- Covering the full length of the protein, no label, no modification, high purity, and maximum close to the natural protein structure.
| Product parameter | |
| Product name(Chinese) | Tau（磷酸化）抗原 |
| Product name(English) | Tau (phosphorylation) antigen |
| Period of validity | 2 Years |
| Storage Conditions | -20℃ |
| Packing specification | 50μg/100μg |
| Feature | Mammalian cells (CHO) recombinant expression |
- Purity
Phosphorylated tau protein>97% by SDS-PAGE
- Reliability
Enzyme-linked immunosorbent assay (ELISA) showed that phosphorylated tau protein could be recognized by a variety of commercially available imported or domestic anti-tau antibodies.
- Phosphorylation
Enzyme-linked immunosorbent (ELISA) test showed that the phosphorylation of pT181, pT217 and pT231 was maintained.
